Cadence is joining the US Department of Energy’s (DOE) Genesis Mission Consortium, a public-private partnership aimed at accelerating scientific discovery through artificial intelligence (AI), high-performance computing (HPC) and advanced engineering technologies.
As part of the collaboration, Cadence will contribute its AI-enabled design and simulation technologies, alongside technical expertise, to support research priorities across advanced microelectronics, quantum and superconducting systems, data centre energy efficiency and AI-driven scientific workflows.
Launched through an executive order in November 2025, the Genesis Mission aims to double the productivity and impact of American science and engineering within a decade. Led by DOE Under Secretary for Science Dr. Darío Gil, the initiative brings together the computing resources, AI systems, experimental facilities and specialised datasets of the country’s 17 National Laboratories.
For Cadence, the partnership provides an opportunity to extend its electronic design automation (EDA) and system design and analysis (SDA) capabilities into broader scientific research applications.
“Cadence has long believed that AI-driven design and physics-based simulation will reshape how critical systems are built – from advanced semiconductors to AI factories and next-generation physical AI and scientific applications,” said Tom Beckley, senior vice president of Strategic Technology Programs at Cadence.
The company added that its participation builds on existing collaborations with several DOE and DOE/National Nuclear Security Administration laboratories, including Sandia National Laboratories, Fermi National Accelerator Laboratory, Oak Ridge National Laboratory, Lawrence Livermore National Laboratory, Argonne National Laboratory and Brookhaven National Laboratory. Its technologies have supported modelling, simulation, verification and large-scale engineering analysis for research aligned with science, energy and national security priorities.
Oak Ridge National Laboratory also highlighted the potential of the partnership to bring advanced engineering tools into scientific research.
“The Genesis Mission represents an extraordinary opportunity to accelerate scientific discovery through AI, high-performance computing and advanced design tools,” said Dr. Jeffrey S. Vetter, corporate fellow and section head of Advanced Computing Systems Research at Oak Ridge National Laboratory.
How Cadence plans to contribute to the Genesis Mission
The firm will be backing the Genesis Mission in 4 ways. It will offer subject-matter expertise, joining the scoping and piloting of AI model development and validation, data standards, and high-performance computing.
It will provide targeted access to its AI-enabled EDA, system design and analysis, multiphysics simulation, digital twin, advanced packaging, and 3D-IC workflows for pilots and demonstrations.
It will support integrating its workflows with DOE laboratory HPC environments, including reproducible packaging and AI performance benchmarking.
It will work with the labs and academic partners on training and curriculum to build the AI-enabled engineering workforce. The company ties all of this to its broader strategy of combining agentic AI, physics-based simulation, digital twins, and high-performance computing across semiconductor design, physical AI systems, and AI factories.
Beyond semiconductor design, the collaboration also reflects the growing role of AI-assisted engineering in areas such as advanced manufacturing, materials science, biotechnology, nuclear energy and quantum information science.
With scientific research increasingly relying on large-scale computing and increasingly complex simulations, integrating specialised engineering tools with national laboratory infrastructure could help researchers accelerate experimentation and validation. Cadence’s participation is intended to bring these capabilities into the Genesis Mission ecosystem, supporting the broader effort to strengthen US scientific and technological competitiveness.
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